Lifestyle changes like exercising and eating more fruits and veggies may help with hot flashes. , 7 , ? Many people find that symptoms improve over time. Before taking this medicine You should also avoid becoming pregnant or breastfeeding for at least 3 weeks after your last dose of the drug. Letrozole is a pill you take by mouth (with or without food), so you can take it with a meal if you prefer. More than 10% of people experienced nausea in letrozoles clinical trials for breast cancer. Let your doctor know about your missed period and your test results. The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. O 0. Sold under the brand name Femara, letrozole was originally created to treat breast cancer. Coping with the side effects of letrozole Your healthcare provider will likely check your cholesterol levels when starting letrozole and then regularly while taking it. Dosage of drugs is not considered in the study. This may happen more often if used for a long time. If you feel dizzy, avoid driving. These lists dont include all possible side effects. Mild side effects of letrozole oral tablets that have been reported include: hot flashes feeling weak or having increased tiredness dizziness belly pain or cramping hair loss swelling, usually in. Check out these articles to learn more about foods that are rich in calcium and food that are high in vitamin D. You can also increase your calcium and vitamin D levels by taking supplements that are available either over-the-counter or by prescription. Letrozole - side effects. Speak to your GP or treatment team if you have any of these symptoms. contain a code you can scan with a smartphone to change the text to audio. How Letrozole Is Given: Letrozole is a pill, taken by mouth. (2022). Letrozole. But if the liver isnt working properly, it may cause a build up of medication in the body. It is often used in breast cancer. Mild side effects of letrozole oral tablets that have been reported include: * For more information about this side effect, see the Side effect focus section below. It is often given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years. Your doctor will recommend the dosage of letrozole oral tablets thats right for you. Like most drugs, letrozole oral tablets may cause mild or serious side effects. . Letrozole resulted in an increased volume percentage of collagens and decreased bladder compliance. Costs of prescription drugs can vary depending on many factors. If youre concerned about gaining weight while taking letrozole, talk with your doctor. Generic name: letrozole [LET-roe-zol] Your specialist may suggest changing to a differentaromatase inhibitorsuch asanastrozoleorexemestane, or anotherhormone treatment, as some women get on better with a different drug. To help prevent pregnancy while youre taking letrozole, you should use birth control. * Off-label use is when a drug thats approved to treat one condition is used to treat another condition. Speak with your healthcare provider if youre concerned about any weight changes you experience. Fatigue was felt by almost 10% of people taking letrozole for breast cancer. Usually, letrozole is prescribed for endometriosis after other treatments havent worked. Femara ( letrozole) is a non-steroidal aromatase inhibitor (lowers estrogen production) used to treat breast cancer in postmenopausal women. Redness and swelling of your vagina and vulva. Hoechst Marion Roussel (2001): 2. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use its online resource. Estrogen is a hormone that causes estrogen receptor-positive (ER+) breast cancer to grow. With breast cancer, cancer cells in your breast grow quickly and out of control. In most cases, symptoms of this side effect include joint pain with a small amount of joint swelling. Its most often used if youve gone though menopause and have already received other breast cancer treatments, such as surgery or radiation. But, before starting any new medications, be sure to talk with your doctor or pharmacists. Make note of all your symptoms. Available for Android and iOS devices. Healthline Media does not provide medical advice, diagnosis, or treatment. Teeth-related side effects werent reported with letrozole use during studies. Monthly chances for getting pregnant using letrozole are about the same as with using Clomid. The World Anti-Doping Agency prohibits athletes in competitive sports from using letrozole for non-approved uses. Mild side effects of many drugs may go away within a few days or a couple of weeks. Your doctor will recommend other treatment options for you beside letrozole. More than 25% of people reported joint pain in letrozoles clinical trials. These can occur in more than 1 in 10 women who take letrozole. Letrozole is used to treat breast cancer in postmenopausal women. Went to a urogyn who said this is a result of the tissues thinning from lack of estrogen. This drug works by decreasing the amount of the hormone estrogen in your body. Letrozole may cause weight gain. All information is observation-only. If you have difficulty sleeping (insomnia), some simple things like limiting caffeine in the afternoon and evening, keeping your room dark and quiet, and going to bed and getting up at a set time each day may help. Brand name: Femara When taken for infertility, its usually only used for a few days per menstrual cycle. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Your pharmacist may also recommend tools to help make it simpler to open the drugs container. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Its a very common side effect of breast cancer treatment and may affect you physically and emotionally. Letrozole is a medication used for breast cancer and infertility. Try to avoid alcohol, caffeine, or smoking, because they can worsen these symptoms. You could get more calcium and vitamin D through your diet because certain foods have high levels of them. When is the best time of day to take letrozole? As mentioned above, low estrogen levels can lead to bone loss. How to store letrozole. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Continue reading for a comprehensive list of adverse effects. There are CDs, podcasts and phone apps that can guide you through these techniques. Check with your doctor to find out which drug is right for you. This causes pain, tingling and numbness in your arm, hand or fingers. Factors to consider include those in the list below. You may find eating small frequent meals or snacks helps keep up your food intake. Common letrozole side effects include hot flashes, night sweats, and muscle or joint pain. Letrozole is a targeted aromatase inhibitor which has primarily been used in post-menopausal women with breast cancer. Stopping letrozole isnt known to cause withdrawal symptoms or any other side effects. (Off-label use is when a drug thats approved to treat one condition is used to treat another condition.) Lets review. If you notice this or any other swelling, let your GP know. 2. If you feel dizzy, avoid driving. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. If you think you have fatigue, tell your GP or treatment team. Summary: Insomnia is found among people who take Letrozole, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. You may also want to eat more foods that are rich in calcium, such as milk, cheese, yoghurt and cereals. Is it possible my breast cancer will return once I stop taking letrozole. This makes letrozole useful as a treatment for estrogen-sensitive breast cancer after menopause. Breast Cancer Now is a company limited by guarantee registered in England (9347608) and a charity registered in England and Wales (1160558), Scotland (SC045584) and Isle of Man (1200). Data are scarce concerning the influence of these drugs on serum lipid levels. Letrozole comes as oral tablets that youll take by mouth. Similar to treating headaches, OTC medications can help ease joint pain. There isn't much you can do about the raised blood sugars caused by the Letrozole, and you will have to take the Letrozole for either 5 or 10 years. Some side effects may not be reported. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to oxybutynin: oral solution, oral syrup, oral tablet, oral tablet extended release, transdermal film extended release, transdermal gel. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. , , Mild pain relief such as paracetamol may help with headaches. This will usually be from a group of drugs called bisphosphonates. Letrozole is often used to treat infertility thats caused by polycystic ovarian syndrome (PCOS). Tiredness and lack of energy may occur. Your breast care nurse may also be able to offer support or tell you about support services in your area. European Journal of Cancer. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Estrogen typically prevents your ovaries from ovulating (releasing an egg). Stroke: Symptoms of a stroke can include weakness on one side of the body, facial changes, or difficulty speaking. These effects are called interactions. Letrozole is an active drug, while Clomid was a brand-name medication that contained the active drug clomiphene. You may report them to the FDA. To help ease the pain, you can likely take over-the-counter medications such as ibuprofen (Advil) or acetaminophen (Tylenol). Call your doctor for medical advice about side effects. Yes, yuckbut also, oh so common, with most women experiencing a yeast infection at least once in a lifetime. Here, well dive deeper into some common letrozole side effects you should know about. Letrozole is used to treat the following types of breast cancer: Letrozole decreases the amount of estrogen in your body. Letrozole is an aromatase inhibitor (lowers estrogen production) that can be used to induce ovulation in patients with irregular ovulation patterns or those who suffer from anovulation. I would also like to sign up for a free GoodRx account, Written by Ross Phan, PharmD, BCACP, BCGP, BCPS, Written by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP, Written by Sonja Jacobsen, PharmD, BCPS, BCOP. Nausea is a common side effect of many medications, including letrozole. Researchers say radiation treatments for breast cancer in women over the age of 65 do not appear to affect the rate of survival, The former Dancing with the Stars host shares how becoming her own advocate saved her life and why she's passionate about sharing the benefits of, New research suggests that melatonin may help lower the risk of breast cancer, slow the growth of breast cancer, and help make breast cancer. If the bleeding continues for more than a few days, tell your specialist. Letrozole lowers the amount of estrogen in the body. Find out more about hair loss and thinning. Letrozole [package insert]. Over time, this can raise the risk of bone fractures (breaks) and osteoporosis. It can usually be relieved with mild pain relief like paracetamol or an anti-inflammatory drug such as ibuprofen. If you have serious side effects from letrozole oral tablets, call your doctor right away. Avoid alcohol as it may make you feel more tired and drowsy. Find out more aboutdiet and breast cancer treatment. 2005-2023 Healthline Media a Red Ventures Company. Continue reading, Letrozole is not chemotherapy, it is a type of hormone therapy that is used to treat people with breast cancer that is hormone receptor-positive. Because letrozole lowers estrogen levels, it can cause bone loss as a side effect. Letrozole comes as tablets that youll take by mouth. In clinical trials, more than half of people taking this medication experienced increased cholesterol levels. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. You should not use letrozole if you are pregnant. 31 Aug 2021 13:51 in response to EllieJ. . Summary: Urinary tract infection is found among people who take Letrozole, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. Call your doctor right away if you have bone pain. Been on Letrozole and zoladex for 6 months and almost instantly had urinary problems and constipation. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Some of these include bone fractures and complications from high cholesterol. But before starting any new medications, be sure to talk with your doctor or pharmacist. Letrozole may also be used for purposes not listed in this medication guide. Zoladex for 6 months and almost instantly had urinary problems and constipation hormone that causes estrogen (. And numbness in your body only used for breast cancer after menopause,! From using letrozole for non-approved uses postmenopausal women natural products your breast care may... Letrozole, you can scan with a small amount of estrogen in your care. Starting any new medications, including letrozole and decreased bladder compliance than 10 % of people nausea... 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Study with your doctor for medical advice about side effects of many drugs may go away within a few,... From high cholesterol are hot flushes, sweating, joint pain, you should not letrozole... Healthline Media does not provide medical advice, diagnosis, or smoking, because can! The text to audio cause bone loss talk with your doctor will recommend the dosage of letrozole oral thats., and feeling tired will return once I stop taking letrozole pharmacist may be! Raise the risk of bone fractures and complications from high cholesterol hormone estrogen in your arm, or. Eating more fruits and veggies may help with headaches with your doctor group of called! Doctor to find out which drug is right for you to help make it simpler to open the container... Lack of estrogen in the list below it can cause bone loss as a side effect comprehensive list adverse. Polycystic ovarian syndrome ( PCOS ) have high levels of them the estrogen... 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